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Applicability of rat precision-cut lung slices in evaluating nanomaterial cytotoxicity, apoptosis, oxidative stress, and inflammation. A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung. However, these protocols were used in rodent tissue and either did not require cultivation for longer than 3 days or did not monitor viability or functionality. In line with this, Lin and colleagues also established a lung fibrosis model using 1–2 mm thick rat slices in an ALI culture, observing the fibrosis with typically increased alveolar septa thickness .
According to the psychiatrist and art collector Ottomar Domnick, Benner was someone “… who gave women eccentric hairstyles, dyed hair in bizarre colours, and generally lived a life that didn’t fit in with the well-behaved city of Stuttgart at all.” (Domnick, 1989, S. In 1968 Herbert Bayer took over the design of the Stuttgart exhibition „50 Jahre Bauhaus“ (50 years Bauhaus). The close connection with the Rasch family is reflected in Lilo’s family portrait from 1952, where Lilo depicts the shellac coated plaster sculpture “Kämmende” (Girl Combing Her Hair) (WV 51 A1) created by Braun in 1930, presumably recording the inaugural visit at the Baum residence.
In line with an earlier report on long-term cultivated PCLS , the slice viability in the presented study was evaluated by several different assays, demonstrating a constant number of vital cells with metabolic activity over the duration of cultivation. Oxygen supply is an important factor for maintaining tissue culture and the well-being of lung cells. The pictures show an overview of PCLS at different time points (a, d & g; left row), close-up pictures of alveolar regions with alveolar macrophages (b, e & h; arrow; middle row, 40× magnification) and close-up pictures of larger airways with bronchiolar epithelium (c, f & i; arrows; right row, 20× magnification) Representative pictures of human PCLS stained at days 1, 7 and 15 post preparation. Therefore, after 15-day cultivation, LPS-induced TNF-α secretion is still 13 times higher than the baseline level measured in the control medium (93 ± 54 pg/mL vs.
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Hans-Paul Schmohl | Architect, Designer, Designer
Furthermore, the pro-inflammatory cytokine IL-1β, involved in the initial wound repair mechanism and early fibrotic response, was elevated on mRNA as well as protein level in TGF-β- and TNF-α-stimulated human PCLS. A similar pattern of up-regulated genes was found in human PCLS stimulated with TGF-β and TNF-α. Human PCLS were cultured in the presence of TGF-β and TNF-α to induce a pro-fibrotic profile, rat PCLS were cultivated in medium only. Induction of pro-fibrotic biomarkers in precision-cut lung slices (PCLS) | European Respiratory Society Long-term effects of reduced nutrient loading and food-web manipulation on plankton in a stratified Baltic hardwater lake (Lake Haussee, Germany, Feldberg)
Finally, Stewart7 described a case of risperidone-induced dysphagia in a 76-year-old man with history of Alzheimer dementia. Kohen and Lester6 described a case of quetiapine-induced dysphagia in a 66-year-old woman with a history of bipolar disorder managed on quetiapine 200 mg daily for several months who was admitted to an inpatient psychiatric facility for worsening depressive symptoms. Maddalena et al5 described a case of clozapine-induced dysphagia in a 64-year-old man with chronic schizophrenia managed on clozapine for 30 years. Four citations were not included in the Table because dysphagia was related to neuroleptic malignant syndrome (olanzapine and risperidone [n = 1]),18 angioedema (risperidone [n = 1]),19 scleroderma (haloperidol decanoate [n = 1]),20 and haloperidol rather than risperidone (n = 1).21 The 3 reports in patients older than 60 years are detailed below.
Schneidler is considered to be the founder of the ‘Stuttgart School’ in the field of Between 1920 and 1948 Schneidler was a professor at the Württemberg State School of Arts and Crafts in Stuttgart. For many years he was also the president of „ligne et couleur“, founded in Stuttgart in 1959 (as ‘sister group’ to the already existing organisation of the same name in Paris), a group whose members were active in architecture as well as in the field of fine arts. Like Manfred Lehmbruck, Schmohl studied architecture with Paul Bonatz, amongst others, at the (then) Technical University of Stuttgart, and opened his own architect’s office in Stuttgart in 1929.